diff --git a/packages/injected/src/bindingsController.ts b/packages/injected/src/bindingsController.ts
index 7f58b482a5f00..cc5f393ae2b14 100644
--- a/packages/injected/src/bindingsController.ts
+++ b/packages/injected/src/bindingsController.ts
@@ -59,11 +59,29 @@ export class BindingsController {
         });
       }
       const payload: BindingPayload = { name: bindingName, seq, serializedArgs };
-      (this._global as any)[this._globalBindingName](JSON.stringify(payload));
+      (this._global as any)[this._globalBindingName](this._stringifyPayload(payload));
       return promise;
     };
   }
 
+  private _stringifyPayload(payload: BindingPayload): string {
+    // The page may define Array.prototype.toJSON/Object.prototype.toJSON (e.g. Prototype.js),
+    // which would corrupt JSON.stringify(payload) into something other than an object with
+    // a serializedArgs array. Temporarily remove them so our own payload serializes correctly.
+    const arrayToJSON = (Array.prototype as any).toJSON;
+    const objectToJSON = (Object.prototype as any).toJSON;
+    try {
+      delete (Array.prototype as any).toJSON;
+      delete (Object.prototype as any).toJSON;
+      return JSON.stringify(payload);
+    } finally {
+      if (arrayToJSON !== undefined)
+        (Array.prototype as any).toJSON = arrayToJSON;
+      if (objectToJSON !== undefined)
+        (Object.prototype as any).toJSON = objectToJSON;
+    }
+  }
+
   removeBinding(bindingName: string) {
     const data = this._bindings.get(bindingName);
     if (data)
diff --git a/tests/page/page-expose-function.spec.ts b/tests/page/page-expose-function.spec.ts
index 79c354791c638..ad6f1ef72d5a3 100644
--- a/tests/page/page-expose-function.spec.ts
+++ b/tests/page/page-expose-function.spec.ts
@@ -235,12 +235,13 @@ it('should work with busted Array.prototype.map/push', async ({ page, server })
   expect(await page.evaluate('add(5, 6)')).toBe(11);
 });
 
-it('should fail with busted Array.prototype.toJSON', async ({ page }) => {
+it('should work with busted Array.prototype.toJSON', { annotation: { type: 'issue', description: 'https://github.com/microsoft/playwright/issues/41359' } }, async ({ page }) => {
   await page.evaluateHandle(() => (Array.prototype as any).toJSON = () => '"[]"');
 
   await page.exposeFunction('add', (a, b) => a + b);
-  await expect(() => page.evaluate(`add(5, 6)`)).rejects.toThrowError('serializedArgs is not an array. This can happen when Array.prototype.toJSON is defined incorrectly');
+  expect(await page.evaluate(`add(5, 6)`)).toBe(11);
 
+  // The page's own override must still be intact after the binding call.
   expect.soft(await page.evaluate(() => ([] as any).toJSON())).toBe('"[]"');
 });