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_pathways/WP127.md

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title: Serum extracellular vesicle microRNAs as potential biomarkers to predict
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pembrolizumab response and prognosis in metastatic non-small cell lung cancer
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patients (2025)
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- link: PMC12593800
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title: Jaw-specific differential kinase activity profiles in human periodontal ligament
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stem cells under mechanical compression (2025)
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communities:
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- ONTOX
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description: 'Interleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5

_pathways/WP1434.md

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- link: PMC12448840
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title: 'GNNenrich: a novel method for pathway enrichment analysis based on graph
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neural network (2025)'
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- link: PMC12593800
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title: Jaw-specific differential kinase activity profiles in human periodontal ligament
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stem cells under mechanical compression (2025)
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communities: []
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description: Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin
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(OPN) through IKK signaling pathway. Proteins on this pathway have targeted assays

_pathways/WP1530.md

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- link: PMC7913660
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title: A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene
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Expression (2021)
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- link: PMC12799884
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title: Advances in genomic and pharmacokinetic profiling for clinical stratification
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of metastatic breast cancer (2025)
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communities:
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- ExRNA
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description: 'This is the first of two pathways which deals with the DNA damage response.

_pathways/WP1531.md

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- link: PMC12532006
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title: 'Dysregulated vitamin D signaling in Hashimoto''s thyroiditis: an integrated
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transcriptomic study in a Korean cohort (2025)'
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- link: PMC10775474
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title: Identifying patterns to uncover the importance of biological pathways on
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known drug repurposing scenarios (2024)
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communities:
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- Micronutrients
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- ONTOX

_pathways/WP1533.md

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- link: PMC10545883
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title: 'Fluid flow shear stress and tissue remodeling-an orthodontic perspective:
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evidence synthesis and differential gene expression network analysis (2023)'
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- link: PMC10775474
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title: Identifying patterns to uncover the importance of biological pathways on
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known drug repurposing scenarios (2024)
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- link: PMC12799884
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title: Advances in genomic and pharmacokinetic profiling for clinical stratification
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of metastatic breast cancer (2025)
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communities:
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- ONTOX
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description: Vitamin B12 is a water soluble, organic compound and essential nutrient

_pathways/WP1584.md

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- link: PMC9473477
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title: 'Network-Based Data Analysis Reveals Ion Channel-Related Gene Features in
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COVID-19: A Bioinformatic Approach (2022)'
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- link: PMC11502557
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title: MicroRNAs from edible plants reach the human gastrointestinal tract and may
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act as potential regulators of gene expression (2024)
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communities:
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- Diseases
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description: 'Insulin resistance is strongly associated with type II diabetes. "Diabetogenic"

_pathways/WP195.md

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- link: PMC12220957
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title: IL-1β signaling modulates T follicular helper and regulatory cells in human
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lymphoid tissues (2025)
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- link: PMC12593800
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title: Jaw-specific differential kinase activity profiles in human periodontal ligament
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stem cells under mechanical compression (2025)
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communities:
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- ONTOX
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- PancCanNet

_pathways/WP1984.md

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- link: PMC10853805
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title: 'HetFCM: functional co-module discovery by heterogeneous network co-clustering
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(2024)'
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- link: PMC12799884
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title: Advances in genomic and pharmacokinetic profiling for clinical stratification
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of metastatic breast cancer (2025)
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communities: []
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description: This pathway incorporates the most important proteins for breast cancer.
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The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine

_pathways/WP2018.md

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- link: PMC11265978
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title: 'Large-scale proteomics in the first trimester of pregnancy predict psychopathology
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and temperament in preschool children: an exploratory study (2024)'
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- link: PMC12593800
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title: Jaw-specific differential kinase activity profiles in human periodontal ligament
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stem cells under mechanical compression (2025)
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communities: []
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description: 'RANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor
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activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG

_pathways/WP205.md

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title: Serum extracellular vesicle microRNAs as potential biomarkers to predict
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pembrolizumab response and prognosis in metastatic non-small cell lung cancer
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patients (2025)
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- link: PMC12593800
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title: Jaw-specific differential kinase activity profiles in human periodontal ligament
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stem cells under mechanical compression (2025)
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communities: []
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description: 'Interleukin-7 (IL-7) was discovered in the year 1988 as a factor that
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enhanced the growth of murine B-cell precursors in bone marrow culture system. It

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