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Integrative Transcriptomics Logo

We are the Integrative Transcriptomics research group at the University of Tübingen, based at the Interfaculty Institute for Bioinformatics and Medical Informatics (IBMI) and led by Prof. Dr. Kay Nieselt.

Our research combines algorithm development, machine learning, and interactive visualization to investigate complex biological systems. We develop computational methods and accessible software for the analysis and interpretation of genomic, transcriptomic, and proteomic data, with a particular interest in microbial biology.

Find out more: Research group · Research projects · Software · Publications

Research Focus

  • Microbial genomics and pangenomics — Genome variation, comparative genomics, bacterial evolution, and the reconstruction and analysis of ancient and modern genomes.
  • Transcriptomics and gene regulation — Differential gene expression, transcription start sites, non-coding RNAs, and prokaryotic transcriptome architecture.
  • Multi-omics and visual analytics — Integrative exploration of heterogeneous biological datasets, functional enrichment, molecular networks, and phylogenetic relationships.
  • Machine learning for biological data — Protein function prediction, sequence classification, dimensionality reduction, and uncertainty-aware data analysis.

Explore our GitHub repositories for additional projects, source code, and documentation.

TueVis – Biomedical Data Visualization

TueVis Logo

We host and maintain TueVis, a centralized platform for discovering and accessing biomedical data visualization tools developed at the Institute for Bioinformatics and Medical Informatics (IBMI) at the University of Tübingen. The platform brings together interactive software solutions across genomics, transcriptomics, proteomics, multi-omics, phylogenomics, and systems biology. By making research-driven visualization tools easily accessible, TueVis supports the exploration, analysis, and interpretation of complex biological datasets.

Popular repositories Loading

  1. DamageProfiler DamageProfiler Public

    A Java based tool to determine damage patterns on ancient DNA as a replacement for mapDamage

    Java 21 3

  2. PTMVision PTMVision Public

    Web application for the interactive visualization and exploration of post-translational modifications of proteins from open and closed search software.

    HTML 7 1

  3. inPHAP inPHAP Public

    Interactive phased haplotype viewer

    Java 6

  4. MUSIAL MUSIAL Public

    Generate comprehensive statistics and alignments, and assess variability at the genome, gene and protein levels, based on VCF files produced from prokaryotic sources.

    Java 5 1

  5. GO-Compass GO-Compass Public

    Visual analytics web tool for comparing multiple Gene Ontology (GO) term lists and reducing redundancy via semantic similarity clustering.

    JavaScript 4 1

  6. trustpca trustpca Public

    Python 4 2

Repositories

Showing 10 of 62 repositories
  • TrepoGen-nextstrain Public

    Nextstrain TrepoGen is a reproducible Nextstrain workflow for tracking bacterial diversity at both genome- and gene-level.

    Integrative-Transcriptomics/TrepoGen-nextstrain's past year of commit activity
    Python 0 GPL-3.0 0 0 0 Updated Nov 9, 2026
  • PhageExpressionAtlas Public

    PhageExpressionAtlas is a web application for interactive exploration of phage infections on the transcriptional level based on dual RNA-seq data.

    Integrative-Transcriptomics/PhageExpressionAtlas's past year of commit activity
    Jupyter Notebook 3 MIT 0 0 0 Updated Nov 6, 2026
  • GO-Compass Public

    Visual analytics web tool for comparing multiple Gene Ontology (GO) term lists and reducing redundancy via semantic similarity clustering.

    Integrative-Transcriptomics/GO-Compass's past year of commit activity
    JavaScript 4 1 3 3 Updated Nov 5, 2026
  • .github Public
    Integrative-Transcriptomics/.github's past year of commit activity
    0 0 0 0 Updated Oct 27, 2026
  • TrepoGen-auspice Public Forked from nextstrain/auspice

    Custom Auspice fork for visualizing global Treponema pallidum data with a focus on outer membrane proteins.

    Integrative-Transcriptomics/TrepoGen-auspice's past year of commit activity
    JavaScript 0 AGPL-3.0 175 0 0 Updated Oct 23, 2026
  • GO-Compass-Trrack Public Forked from Integrative-Transcriptomics/GO-Compass

    Visual navigation of multiple lists of GO terms with Trrack.js for provenance tracking.

    Integrative-Transcriptomics/GO-Compass-Trrack's past year of commit activity
    JavaScript 1 1 0 0 Updated Oct 19, 2026
  • Integrative-Transcriptomics/deconv-bench-v2's past year of commit activity
    Python 0 MIT 0 0 0 Updated Oct 13, 2026
  • PhageGAP Public

    Interactive web application for functional annotation of bacteriophage proteins.

    Integrative-Transcriptomics/PhageGAP's past year of commit activity
    Python 0 GPL-3.0 0 0 0 Updated Sep 29, 2026
  • PhageGAP-model Public

    Training, testing and application of the ML model used for PhageGAP.

    Integrative-Transcriptomics/PhageGAP-model's past year of commit activity
    Jupyter Notebook 0 GPL-3.0 0 0 0 Updated Sep 29, 2026
  • Shiny_DESeq2 Public
    Integrative-Transcriptomics/Shiny_DESeq2's past year of commit activity
    R 1 0 6 0 Updated Aug 5, 2026

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